Динамика изменений поведения крыс после разрушения Locus coeruleusстатья
Статья опубликована в журнале из списка RSCI Web of Science
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 марта 2017 г.
Аннотация:Destruction of Locus coeruleus (LC) was conducter in adult rats (male rats of the Wistar line, 250-300 g) electrolytically or by means of 6-hydroxidopamine (6-OHDA). Behaviour of the intatact animals, shamoperated and of rats with destructed LC was evaluated before and every week after the operation during 5 weeks. Statistically significant alterations in the behaviour were revealed only in the initially low-active rats. These animals were characterized firstly, by low motor and exploratory activity in all tests (open field and automated devices), disturbance of the reactivity to novelty - only in one week after the operation with subsequent compensation of shifts; secondly, by low level of investigatory activity in open field and absence of habituation to the repetitive tests - from the 21st day after the operation.