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Progestins as Anticancer Drugs and Chemosensitizers, New Targets and Applicationsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Fedotcheva Tatiana A., Fedotcheva Nadezhda I., Shimanovsky Nikolai L.
- Журнал: Pharmaceutics
- Том: 13
- Номер: 10
- Год издания: 2021
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1616
- DOI: 10.3390/pharmaceutics13101616
- Аннотация: Progesterone and its synthetic analogues, progestins, participate in the regulation of cell differentiation, proliferation and cell cycle progression. Recently, their effectiveness in the treatment of hormone-sensitive tumors was revealed. According to current data, the anticancer activity of progestins is mainly mediated by their cytotoxic and chemosensitizing influence on different cancer cells. In connection with the detection of previously unknown targets of the progestin action, which include the membrane-associated progesterone receptor (PR), non-specific transporters related to the multidrug resistance (MDR) and mitochondrial permeability transition pore (MPTP), and checkpoints of different signaling pathways, new aspects of their application have emerged.
- Добавил в систему: Федотчева Надежда Ивановна