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Two-scale haemodynamic modelling for patients with Fontan circulationстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Dobroserdova Tatiana K., Vassilevski Yuri V., Simakov Sergey S., Gamilov Timur M., Svobodov Andrey A., Yurpolskaya Lyudmila A.
- Журнал: Russian Journal of Numerical Analysis and Mathematical Modelling
- Том: 36
- Номер: 5
- Год издания: 2021
- Издательство: V S P
- Местоположение издательства: Netherlands
- Первая страница: 267
- Последняя страница: 278
- DOI: 10.1515/rnam-2021-0022
- Аннотация: Palliation of congenital single ventricle heart defects suggests multi-stage surgical interventions that divert blood flow from the inferior and superior vena cava directly to the right and left pulmonary arteries, skipping the right ventricle. Such system with cavopulmonary anastomoses and single left ventricle is called Fontan circulation, and the region of reconnection is called the total cavopulmonary connection (TCPC). Computational blood flow models allow clinicians to predict the results of the Fontan operation, to choose an optimal configuration of TCPC and thus to reduce negative postoperative consequences. We propose a two-scale (1D3D) haemodynamic model of systemic circulation for a patient who has underwent Fontan surgical operation. We use CT and 4D flow MRI data to personalize the model. The model is tuned to patient's data and is able to represent measured time-averaged flow rates at the inlets and outlets of TCPC, as well as pressure in TCPC for the patient in horizontal position.We demonstrate that changing to quiescent standing position leads to other patterns of blood flow in regional (TCPC) and global haemodynamics. This confirms clinical data on exercise intolerance of Fontan patients. © 2021 Walter de Gruyter GmbH, Berlin/Boston. Keywords: boundary conditions; Fontan circulation; haemodynamics; multiscale model; TCPC
- Добавил в систему: Ильин Александр Владимирович