Study of age-dependent structural and functional changes of mitochondria in skeletal muscles and heart of naked mole rats (Heterocephalus glaber)

Holtze, S.; Eldarov, C.M.; Vays, V.B.; Vangeli, I.M.; Vysokikh, M.Y.; Bakeeva, L.E.; Skulachev, V.P.; Hildebrandt, T.B.

Авторы: Holtze S., Eldarov C.M., Vays V.B., Vangeli I.M., Vysokikh M.Yu, Bakeeva L.E., Skulachev V.P., Hildebrandt T.B.
Журнал: Biochemistry (Moscow)
Том: 81
Номер: 12
Год издания: 2016
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1429
Последняя страница: 1437
DOI: 10.1134/s000629791612004x
Аннотация: Morphometric analysis of mitochondria in skeletal muscles and heart of 6- and 60-month-old naked mole rats (Heterocephalus glaber) revealed a significant age-dependent increase in the total area of mitochondrial cross-sections in studied muscle fibers. For 6- and 60-month-old animals, these values were 4.8 ± 0.4 and 12.7 ± 1.8%, respectively. This effect is mainly based on an increase in the number of mitochondria. In 6-month-old naked mole rats, there were 0.23 ± 0.02 mitochondrial cross-sections per µm2 of muscle fiber, while in 60-month-old animals this value was 0.47 ± 0.03. The average area of a single mitochondrial cross-section also increased with age in skeletal muscles - from 0.21 ± 0.01 to 0.29 ± 0.03 µm2. Thus, naked mole rats show a drastic enlargement of the mitochondrial apparatus in skeletal muscles with age due to an increase in the number of mitochondria and their size. They possess a neotenic type of chondriome accompanied by specific features of mitochondrial functioning in the state of oxidative phosphorylation and a significant decrease in the level of matrix adenine nucleotides.
Добавил в систему: Высоких Михаил Юрьевич

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Study of age-dependent structural and functional changes of mitochondria in skeletal muscles and heart of naked mole rats (Heterocephalus glaber)статья

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