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LIPIDS PEROXIDATION PRODUCTS IN YOUNG MEN WITH TYPE 1 DIABETES MELLITUSстатья
- Авторы: Darenskaya M.A., Chugunova E.V., Kolesnikov S.I., Semenova N.V., Kolesnikova L.I.
- Журнал: International Journal of Biomedicine
- Том: 12
- Номер: 2
- Год издания: 2022
- Первая страница: 232
- Последняя страница: 236
- DOI: 10.21103/Article12(2)_OA5
- Аннотация: TYPE 1 DIABETES MELLITUS, MEN, DIABETES DURATION, LIPID PEROXIDATION, ANTIOXIDANT DEFENSE The aim of this research was to assess the level of lipid oxidation products level and the antioxidant defense state in young male patients with type 1 diabetes mellitus (T1DM) depending on the disease duration. Materials and Methods: A total of 57 men of young reproductive age (average age of 30.25±8.51 years) with T1DM and an unsatisfactory glycemic profile, depending on the disease duration, were divided into 2 groups. Group 1 included 29 men (average age of 27.69±6.92 years) with a T1DM duration <5 years (2.72±1.61 years) and HbA1c level of 11.37±2.74%. Group 2 included 28 men (average age of 32.89±9.28 years) with a T1DM duration ≥5 years (12.93±5.69) and HbA1c level of 10.19±2.18%). The control group consisted of 28 men of the same age (29.71±4.59 years). Spectrophotometric/spectrofluorometric methods and enzyme immunoassay were used. Results: We found a significant increase in the values of CDs (by 2.04 times, P <0.0001), KD and CT (by 2.38 times, P <0.0001), TBARs (by 1.17 times, P =0.001), SB (by 2.6 times, P <0.0001), and retinol (by 1.44 times, P <0.0001) in Group 1 compared to the control group. In Group 2, there was a statistically significant increase in the levels of CDs (by 2.59 times, P <0.0001), KD and CT (by 2.94 times, P <0.0001), TBARs (by 1.49 times, P =0.001), SB (by 3.27 times, P <0.0001), and retinol (by 1.4 times, P =0.001) compared to the control group. The differences between the two groups with different duration of T1DM were characterized only by the CDs level, which was increased in Group 2 patients with a T1DM duration of ≥5 years (by 1.27 times, P =0.048) compared to Group 1 patients with a T1DM duration of < 5 years. Conclusion: LPO parameters can serve as additional laboratory markers that characterize the course of T1DM and can be used to develop potential prevention and therapy strategies.
- Добавил в систему: Колесников Сергей Иванович