Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Авторы: Ramírez-Morales Maria Antonieta, Goldt Anastasia E., Kalachikova Polina M., B Javier A.Ramirez, Suzuki Masashi, Zhigach Alexey N., Salah Asma Ben, Shurygina Liliya I., Shandakov Sergey D., Zatsepin Timofei, Krasnikov Dmitry V., Maekawa Toru, Nikolaev Evgeny N., Nasibulin Albert G.
Журнал: Nanomaterials
Том: 12
Номер: 16
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 2869
DOI: 10.3390/nano12162869
Аннотация: Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.
Добавил в систему: Зацепин Тимофей Сергеевич

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