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Analysis of the monovalent ion fluxes in U937 cells under the balanced ion distribution: Recognition of ion transporters responsible for changes in cell ion and water balance during apoptosisстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 августа 2017 г.
- Авторы: Vereninov A.A., Goryachaya T.S., Moshkov A.V., Vassilieva I.O., Yurinskaya V.E., Lang F., Rubashkin A.A.
- Журнал: Cell Biology International
- Том: 31
- Номер: 4
- Год издания: 2007
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 382
- Последняя страница: 393
- DOI: 10.1016/j.cellbi.2007.01.023
- Аннотация: Unidirectional 22Na, Li+ and Rb+ fluxes and net fluxes of Na+ and K+ were measured in U937 human leukemic cells before and after induction of apoptosis by staurosporine (1 μM, 4 h) to answer the question which ion transporter(s) are responsible for changes in cell ion and water balance at apoptosis. The original version of the mathematical model of cell ion and water balance was used for analysis of the unidirectional ion fluxes under the balanced distribution of major monovalent ions across the cell membrane. The values of all major components of the Na+ and K+ efflux and influx, i.e. fluxes via the Na+,K+-ATPase pump, Na+ channels, K+ channels, Na/Na exchanger and Na-Cl symport were determined. It is concluded that apoptotic cell shrinkage and changes in Na+ and K+ fluxes typical of apoptosis in U937 cells induced by staurosporine are caused by a complex decrease in the pump activity, Na-Cl symport and integral Na+ channel permeability.
- Добавил в систему: Рубашкин Андрей Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Vereninov...Rubashkin-Cell_Biol_Int-2007.pdf | 417,5 КБ | 1 июля 2021 [RubashkinAA] |