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MBCL-04. 5 – AZACYTIDINE IN TREATMENT OF CHILDREN WITH DE NOVO AND RELAPSED METASTATIC MEDULLOBLASTOMA: RESULTS OF INTERCENTER PILOT STUDYтезисы доклада
- Авторы: Levashov Andrey, Khochenkov Dmitry, Stroganova Anna, Ryzhova Marina, Gorelyshev Sergey, Kadirov Shavkat, Zagidullina Svetlana, Babelyan Stepan, Subbotina Natalya, Mentkevich Georgy, Sidelnikov Dmitry, Daylidite Vidmante, Grigorenko Vasily
- Сборник: Neuro - oncology
- Серия: Vlume 22, Suppl.3,
- Том: 22
- Тезисы
- Год издания: 2020
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: iii387
- Последняя страница: iii387
- DOI: 10.1093/neuonc/noaa222.480
- Аннотация: The aim of this study was to estimate treatment toxicity and event-freesurvival (EFS) according to therapeutic program, MYC/MYC-N gene amplificationand MGMT/DNMT (1, 3a, 3b) proteins expression in tumor cells. From 2016 to 2018 twenty four patients were included in trial. Childrenunderwent adjuvant therapy: craniospinal radiation (CSI) or local radiationtherapy (RT) to the relapsed site up to 23.4Gy with 5-azacytidine, 2 cycles methotrexate/ 5-azacytidine/cisplatin/etoposide, 3 cycles 5-azacytidine/temozolomide - for relapsed group (arm A, n = 5); for patients with de novo medulloblastoma: arm B, n = 11 – vincristine/cyclophosphamide/cisplatin/etoposide (OPEC) - based induction, CSI 36Gy + local RT to the tumor bed up to 54Gy with 5-azacytidine, 1 cycle OPEC and 2 cycles thiophosphamide/carboplatin with auto stem cell transplantation (auto-SCT); arm C, n = 8 – cyclophosphamide/cisplatin - based induction, CSI 23.4 Gy followed by 2cycles 5-azacytidine/thiophosphamide/carboplatin with auto-SCT, localRT with 5-azacytidine. The combination of 5-azacytidine with local RT or temozolomide was safety and tolerability. Arm C was discontinued due to severe gastrointestinal grade 3/4 toxicity, hemorrhagic syndrome after combination of 5-azacytidine with thiophosphamide/ carboplatin. EFS was 0% in arm A, 53.0 ± 15.5%, 50.0 ± 17.7% in arms B and C, a median follow-up 8.8 ± 1.1 months (arm A), 18.8 ± 2.5 months (arm B), 25.0 ± 4.4 months (arm C). Addition of 5-azacytidine to RT or chemotherapy did not improve EFS of patients with MYC/MYC-N gene amplification positive tumor. There was not determined any prognostic significance of MGMT/DNMT (1, 3a,3b) proteins expression in this cohort.
- Добавил в систему: Левашов Андрей Сергеевич