|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibitionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 апреля 2017 г.
- Авторы: Borodkina Aleksandra V., Shatrova Alla N., Deryabin Pavel I., Grukova Anastasiya A., Nikolsky Nikolay N., Burova Elena B.
- Журнал: Cell Cycle
- Том: 15
- Номер: 1
- Год издания: 2016
- Издательство: Landes Bioscience
- Местоположение издательства: United States
- Первая страница: 117
- Последняя страница: 127
- DOI: 10.1080/15384101.2015.1121326
- Аннотация: Previously we demonstrated that endometrium-derived human mesenchymal stem cells (hMESCs) via activation of the ATM/p53/p21/Rb pathway enter the premature senescence in response to oxidative stress. Down regulation effects of the key components of this signaling pathway, particularly ATM and p53, on a fate of stressed hMESCs have not yet been investigated. In the present study by using the specific inhibitors Ku55933 and Pifithrin-α, we confirmed implication of both ATM and p53 in H(2)O(2)-induced senescence of hMESCs. ATM or p53 down regulation was shown to modulate differently the cellular fate of H(2)O(2)-treated hMESCs. ATM inhibition allowed H(2)O(2)-stimulated hMESCs to escape the permanent cell cycle arrest due to loss of the functional ATM/p53/p21/Rb pathway, and induced bypass of mitosis and re-entry into S phase, resulting in tetraploid cells. On the contrary, suppression of the p53 transcriptional activity caused a pronounced cell death of H(2)O(2)-treated hMESCs via autophagy induction. The obtained data clearly demonstrate that down regulation of ATM or p53 shifts senescence of human endometrial stem cells toward tetraploidization or autophagy.
- Добавил в систему: Шатрова Алла Николаевна