Аннотация:MASTER OT J042553.42-402420.7 discovery as possibly counterpart of GRB 220921AAT2022vjwMASTER-SAAO auto-detection system ( Lipunov et al., "MASTER Global Robotic Net", Advances in Astronomy, 2010, 30L ) discovered OT source at (RA, Dec) = 04h 25m 53.42s -40d 24m 20.7s on 2022-09-21.82255 UT during Fermi trigger 685451164 inspection(T0=2022-09-21 11:05:59.07) (Lipunov et al. GCN 32569, Fermi-LAT GCN 32568, also detected by GECAM-B)https://master.sai.msu.ru/site/master2/event.php?id=2097239 .The OT unfiltered magnitude is 17.8m (automatic), mlim=19.8.The OT is seen in 24 images. There is no minor planet at this place.We have 600 reference images without any OT since 2014, for ex., on 2018-11-12.98741 UT with unfiltered mlim=20.3m.Spectral observations are required.There is possible host galaxy in VIZIER database (DES, rmag=24.3)