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New insights into the centrosome-associated spliceosome components as regulators of ciliogenesis and tissue identityстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Busselez Johan, Uzbekov Rustem E., Franco Brunella, Pancione Massimo
- Журнал: Wiley interdisciplinary reviews. RNA
- Номер: E1776
- Год издания: 2023
- Издательство: Wiley
- Местоположение издательства: Singapore
- DOI: 10.1002/wrna.1776
- Аннотация: Biomolecular condensates are membrane-less assemblies of proteins andnucleic acids. Centrosomes are biomolecular condensates that play a crucialrole in nuclear division, cytoskeletal remodeling, and cilia formation in animalcells. Spatial omics technology is providing new insights into the dynamicexchange of spliceosome components between the nucleus and the centro-some/cilium. Intriguingly, centrosomes are emerging as cytoplasmic sites forinformation storage, enriched with RNA molecules and RNA-processing pro-teins. Furthermore, growing evidence supports the view that nuclearspliceosome components assembled at the centrosome function as potentialcoordinators of splicing subprograms, pluripotency, and cell differentiation.In this article, we first discuss the current understanding of the centro-some/cilium complex, which controlsboth stem cell differentiation andpluripotency. We next explore the molecular mechanisms that govern splic-ing factor assembly and disassemblyaround the centrosome and examinehow RNA processing pathways contribute to ciliogenesis. Finally, we dis-cuss numerous unresolved compelling questionsregarding the centrosome-associated spliceosome components and transcript variants within the cyto-plasm as sources of RNA-based secondary messages in the regulation of cellidentity and cell fate determination.
- Добавил в систему: Узбеков Рустем Эдуардович