The Synthesis and Properties of a New Carrier for Paclitaxel and Doxorubicin Based on the Amphiphilic Copolymer of N-vinyl-2-pyrrolidone and Acrylic Acid

Nechaeva, A.M.; Artyukhov, A.A.; Luss, A.L.; Shtilman, M.I.; Svistunova, A.Y.; Motyakin, M.V.; Levina, I.I.; Krivoborodov, E.G.; Toropygin, I.Y.; Chistyakov, E.M.; Tsatsakis, A.M.; Gurevich, L.; Mezhuev, Y.O.

Авторы: Nechaeva Anna M., Artyukhov Alexander A., Luss Anna L., Shtilman Mikhail I., Svistunova Alina Yu, Motyakin Mikhail V., Levina Irina I., Krivoborodov Efrem G., Toropygin Ilya Yu, Chistyakov Evgeniy M., Tsatsakis Aristides M., Gurevich Leonid, Mezhuev Yaroslav O.
Журнал: Macromolecular Chemistry and Physics
Том: 223
Номер: 17
Год издания: 2022
Издательство: John Wiley & Sons Ltd.
Местоположение издательства: United Kingdom
Номер статьи: 2200081
DOI: 10.1002/macp.202200081
Аннотация: This paper deals with the development of polymeric nanocarriers based onamphiphilic copolymers ofN-vinyl-2-pyrrolidone and acrylic acid of variousmolecular weights synthesized through the AIBN-initiated radicalcopolymerization ofN-vinyl-2-pyrrolidone and acrylic acid in the presence ofn-octadecyl mercaptan. The structure of the copolymers is characterized by1НNMR,13СNMR, IR and MALDI-TOF MS spectroscopy. It is shown that thelength of the hydrophilic block defines the size of the nanoaggregates whileimpacting the steric stabilization efficiency and the probability of theinterchain hydrogen bond formation. The hydrogen bonds formation betweenthe residues ofN-vinyl-2-pyrrolidone and acrylic acid is in agreement with thereduction of the𝜻-potential of the nanoaggregates and the critical aggregationconcentrations upon increasing the molecular weight. The presence of acrylicacid residues in the amphiphilic macromolecules leads to a higher affinity fordoxorubicin and slow partial release of doxorubicin bonded with theaggregates’ corona, which is helpful for reducing its cardiac toxicity.Nanoaggregates with a paclitaxel-loaded hydrophobic core are obtained,showing the possibility of dual loading. The amphiphilic copolymers ofN-vinyl-2-pyrrolidone and acrylic acid containing octadecyl thio endgroup are thus promising candidates for combination cancer therapy withimmobilized anti-cancer drugs, paclitaxel, and doxorubicin
Добавил в систему: Нечаева Анна Михайловна

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The Synthesis and Properties of a New Carrier for Paclitaxel and Doxorubicin Based on the Amphiphilic Copolymer of N-vinyl-2-pyrrolidone and Acrylic Acidстатья