Аннотация:The waveguide type biosensors for noninvasive glucose detection based on LSPR of silver nanoparticles were fabricated by thermal diffusion in UV-irradiated photo-thermo-refractive (PTR) glasses and by ion-exchange method in sodiumborosilicate glasses in water vapor atmosphere. The optical and structural properties of the obtained nanocomposites were investigated. The D-glucose/D-galactose binding protein (GGBP) was chosen as a sensitive element of biosensor and successable immobilized on top of PTR glass. The change in absorption spectra were judged due to the presence of GGBP on the substrate surface.