DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n)

Авторы: Arutyunyan Albert F., Kostyukov Alexey A., Lushpa Vladislav A., Mineev Konstantin S., Korolev Sergey P., Gottikh Marina B., Klimova Regina R., Kushch Alla A., Kalabina Kseniya V., Susova Olga Yu, Zhuze Alexei L.
Журнал: Medicinal Chemistry Research
Год издания: 2023
Издательство: Birkhaeuser
Местоположение издательства: United States
DOI: 10.1007/s00044-023-03017-x
Аннотация: A new series of AT-specific minor groove DNA ligands (DB3P(n); n = 1,2,3,4) was synthesized and their spectral, biological and virological properties were investigated. With a methylene spacers of different lengths blocks of three AT pairs located at different distances from each other could be recognized. The compounds synthesized suppressed the activity of HIV-1 integrase at submicromolar concentrations (0.25–0.50 µМ). Also, DB3P(n) were found to be effective inhibitors of simplex virus type I and DNA topoisomerase I. The synthesized DB3P(n) demonstrated good solubility in water, could penetrate through cell and nuclear membranes, and stain DNA in live cells.
Добавил в систему: Костюков Алексей Александрович

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