Degradable covalently-linked siloxane-phosphazene polymer for drug loading and releasing

Авторы: Chernysheva Anna I., Karpova Ekaterina A., Terentyeva Daria A., Tsivkovsky Nikita S., Selivantev Yuriy M., Raitman Oleg A., Gorlov Mikhail V., Soldatov Mikhail A.
Журнал: Reactive and Functional Polymers
Том: 182
Год издания: 2023
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 105491
DOI: 10.1016/j.reactfunctpolym.2022.105491
Аннотация: A novel porous hydrolytically degradable cross-linked polymer was obtained via polycondensation reaction between hexaphenoxycyclotriphosphazene and octa(tetramethylammonium)silicate. The synthesized polymer was characterized by solid NMR, FTIR, nitrogen adsorption etc. This polymer showed perspectives in the use as container for loading and releasing of drug, which was shown with the use of Rhodamine-6G (Rh6G) as model compound. It was shown that due to the presence of hydrolytically unstable P-O-Si fragments the obtained porous polymer can load Rhodamine-6G and release it with various rates, depending on pH value of the medium.
Добавил в систему: Цивковский Никита Сергеевич

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