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Degradable covalently-linked siloxane-phosphazene polymer for drug loading and releasingстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Chernysheva Anna I., Karpova Ekaterina A., Terentyeva Daria A., Tsivkovsky Nikita S., Selivantev Yuriy M., Raitman Oleg A., Gorlov Mikhail V., Soldatov Mikhail A.
- Журнал: Reactive and Functional Polymers
- Том: 182
- Год издания: 2023
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 105491
- DOI: 10.1016/j.reactfunctpolym.2022.105491
- Аннотация: A novel porous hydrolytically degradable cross-linked polymer was obtained via polycondensation reaction between hexaphenoxycyclotriphosphazene and octa(tetramethylammonium)silicate. The synthesized polymer was characterized by solid NMR, FTIR, nitrogen adsorption etc. This polymer showed perspectives in the use as container for loading and releasing of drug, which was shown with the use of Rhodamine-6G (Rh6G) as model compound. It was shown that due to the presence of hydrolytically unstable P-O-Si fragments the obtained porous polymer can load Rhodamine-6G and release it with various rates, depending on pH value of the medium.
- Добавил в систему: Цивковский Никита Сергеевич