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Comparative Analysis of Quantitative Parameters of Expression of the Retinoic Acid Nuclear Receptor RARα Gene and APE1/YB-1/MDR1 Pattern Genes in Patients with Newly Detected Multiple Myelomaстатья
- Авторы: Kalitin N.N., Chernykh Yu B., Buravtsova I.V.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 164
- Номер: 1
- Год издания: 2017
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 90
- Последняя страница: 94
- DOI: 10.1007/s10517-017-3931-7
- Аннотация: The expression of retinoic acid nuclear receptor gene RARα and its relationship with expression of APE1, YB-1, and MDR1 genes was studied in bone marrow aspiration biopsy specimens from 22 patients with newly detected multiple myeloma. The expression of RARα directly correlated with the expression of APE1/YB-1/MDR1 pattern genes. Groups differing by expression of RARα exhibited significant differences in the overall survival of patients; concordant and simultaneous changes in the expression of all genes of the APE1/YB-1/MDR1 pattern suggested the level of RARα gene expression as a potential prognostic factor in the pathogenesis of multiple myeloma.
- Добавил в систему: Калитин Николай Николаевич