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New 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione derivative as an allosteric modulator of the glutamatergic systemстатья
- Авторы: Golubeva Elena A., Lavrov Mstislav I., Veremeeva Polina N., Bovina Evgenia M., Radchenko Eugene V., Topchiy Maxim A., Asachenko Andrey F., Zamoyski Vladimir L., Grigoriev Vladimir V., Palyulin Vladimir A.
- Журнал: Mendeleev Communications
- Том: 33
- Номер: 1
- Год издания: 2023
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 70
- Последняя страница: 72
- DOI: 10.1016/j.mencom.2023.01.022
- Аннотация: An optimized synthesis of N-{5-[(1,11-dimethyl-4,8,12-trioxo-3,6,9-triazatricyclo[7.3.1.13,11]tetradec-6-yl)methyl]-indan-2-yl}-1,3-benzodioxole-5-carboxamide has been carried out from indan-2-one oxime in seven steps. In vitro studies using electrophysiological patch clamp technique have revealed a positive modulation effect of this compound on kainate induced currents in Purkinje neurons in a wide range of concentrations from 10–12 to 10–8 M.
- Добавил в систему: Радченко Евгений Валерьевич