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Germ Granules in Animal Oogenesisстатья
- Авторы: Dobrynin Mikhail A., Bashendjieva Ekaterina O., Enukashvily Natella I.
- Журнал: JOURNAL OF DEVELOPMENTAL BIOLOGY
- Том: 10
- Номер: 4
- Год издания: 2022
- Номер статьи: 43
- DOI: 10.3390/jdb10040043
- Аннотация: In eukaryotic cells, many macromolecules are organized as membraneless biomolecular condensates (or biocondensates). Liquid–liquid and liquid–solid phase transitions are the drivers of the condensation process. The absence of membrane borders makes biocondensates very flexible in their composition and functions, which vary in different cells and tissues. Some biocondensates are specific for germ line cells and are, thus, termed germ granules. This review summarizes the recent data on the composition of germ granules and their functions in gametes. According to these data, germ granules are involved in the determination of germline cells in some animals, such as Amphibia. In other animals, such as Mammalia, germ granules are involved in the processes of transposons inactivation and sequestration of mRNA and proteins to temporarily decrease their activity. The new data on germ granules composition and functions sheds light on germ cell differentiation and maturation properties.
- Добавил в систему: Енукашвили Натэлла