Determination of the conversion products of toxic organophosphorus substances in construction materials using high-performance liquid chromatography with tandem mass spectrometryстатья
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Дата последнего поиска статьи во внешних источниках: 26 июня 2024 г.
Аннотация:After completing the Program for the Destruction of Chemical Weapons (CW) in September 2017, the Russian Federation converts CW destruction facilities for their further use for civilian purposes. An essential measure in the reprofiling of these facilities is the assessment of possible residual contamination and the identification of unrecorded facts of contamination with toxic organophosphorus substances (organophosphorus toxicants, OPTs) or reaction masses (RM) from the neutralization of the infrastructure of the former CW destruction facilities. This paper presents a procedure for a multipurpose screening of 11 conversion products of three OP nerve agents: O-isobutyl-S-(2-diethylaminoethyl)methylphosphonothioate (VR), isopropyl ester of methylphosphonofluoridic acid (Sarin, GB), pinacolyl ester of methylphosphonofluoridic acid (Soman, GD), and VR itself (as the most persistent OP nerve agents) in construction materials. Screening of all analytes, significantly differing in their physicochemical properties, is carried out within single analysis by high-performance liquid chromatography with tandem mass-selective detection (HPLC–MS/MS). A procedure is proposed for the collection of wipe samples from surfaces and solid samples of construction materials with various matrix composition.