Аннотация:The combination of biocompatibility, biodegradability, and high mechanical strength hasprovided a steady growth in interest in the synthesis and application of lactic acid-based polyesters forthe creation of implants. On the other hand, the hydrophobicity of polylactide limits the possibilitiesof its use in biomedical fields. The ring-opening polymerization of L-lactide, catalyzed by tin (II)2-ethylhexanoate in the presence of 2,2-bis(hydroxymethyl)propionic acid, and an ester of polyethylene glycol monomethyl ester and 2,2-bis(hydroxymethyl)propionic acid accompanied by the introduction of a pool of hydrophilic groups, that reduce the contact angle, were considered. Thestructures of the synthesized amphiphilic branched pegylated copolylactides were characterized by1H NMR spectroscopy and gel permeation chromatography. The resulting amphiphilic copolylactides, with a narrow MWD (1.14–1.22) and molecular weight of 5000–13,000, were used to prepareinterpolymer mixtures with PLLA. Already, with the introduction of 10 wt% branched pegylatedcopolylactides, PLLA-based films had reduced brittleness, hydrophilicity, with a water contact angleof 71.9–88.5◦, and increased water absorption. An additional decrease in the water contact angle,of 66.1◦, was achieved by filling the mixed polylactide films with 20 wt% hydroxyapatite, whichalso led to a moderate decrease in strength and ultimate tensile elongation. At the same time, thePLLA modification did not have a significant effect on the melting point and the glass transitiontemperature; however, the filling with hydroxyapatite increased the thermal stability.