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Comprehensive semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosisстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Chernykh VyacheslavB, Sedova AnnaO, Shtaut MariaI, Bragina ElizavetaE, Sorokina TatyanaM, Shmarina GalinaV, Andreeva MarinaV, Kurilo LyubovF, Krasovskiy StanislavA, Polyakov AleksanderV
- Журнал: Asian Journal of Andrology
- Том: 25
- Номер: 0
- Год издания: 2023
- Издательство: Shanghai Institute of Materia Medica
- Местоположение издательства: China
- Первая страница: 1
- Последняя страница: 7
- DOI: 10.4103/aja2022115
- Аннотация: We examined a cohort of 93 cystic fibrosis (CF) male patients who were pancreatic-sufficient (PS-CF; n=40) or pancreatic-insufficient(PI-CF; n = 53). Complex semen examination was performed, including standard semen analysis, quantitative karyological analysis(QKA) of immature germ cells (IGCs), transmission electronic microscopy (TEM), biochemical analysis, and sperm DNA fragmentationby terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling (TUNEL) assay. Azoospermia was diagnosed in 83(89.2%) patients. The other 10 (10.8%) patients were found to be nonazoospermic and showed various spermatological diagnoses(asthenozoospermia, n = 2; asthenoteratozoospermia, n = 3; oligoasthenozoospermia, n = 1; oligoasthenoteratozoospermia, n = 3; andnormozoospermia, n = 1) with no specific morphological abnormalities. Oligospermia was detected in 89.2% azoospermic and 30.0%nonazoospermic patients. Low seminal pH (<7.0) was found in 74 (89.2%) of 83 azoospermic patients. Moderate leukocytospermia(2.0 × 106–2.2 × 106 ml−1) was revealed in 2.4% azoospermic and 40.0% nonazoospermic semen samples. The signs of partialmeiotic arrest at prophase I were found in 4 of 6 nonazoospermic patients examined by QKA of IGCs. The content of fructose andcitrate was low in oligospermic and normal in nonoligospermic semen samples. An increased percentage (>30%) of spermatozoawith noncondensed (“immature”) chromatin was revealed in 2 of 6 nonazoospermic semen samples analyzed by TEM.
- Добавил в систему: Брагина Елизавета Ефимовна
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