Novel Siloxane Derivatives as Membrane Precursors for Lactate Oxidase Immobilization

Авторы: Vokhmyanina Darya V., Sharapova Olesya E., Buryanovataya Ksenia E., Karyakin Arkady A.
Журнал: Sensors
Том: 23
Номер: 8
Год издания: 2023
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 4014
DOI: 10.3390/s23084014
Аннотация: We report new enzyme-containing siloxane membranes for biosensor elaboration. Lactate oxidase immobilization from water–organic mixtures with a high concentration of organic solvent (90%) leads to advanced lactate biosensors. The use of the new alkoxysilane monomers—(3-aminopropyl)trimethoxysilane (APTMS) and trimethoxy[3-(methylamino)propyl]silane (MAPS)—as the base for enzyme-containing membrane construction resulted in a biosensor with up to a two times higher sensitivity (0.5 A·M−1·cm−2) compared to the biosensor based on (3-aminopropyl)triethoxysilane (APTES) we reported previously. The validity of the elaborated lactate biosensor for blood serum analysis was shown using standard human serum samples. The developed lactate biosensors were validated through analysis of human blood serum
Добавил в систему: Вохмянина Дарья Владимировна

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