Cobalt and iron bis(dicarbollide) conjugates with cholesterol: synthesis and evaluation of antiproliferative activity

Авторы: Erdelyi K.E., Antonets Anastasiya А., Zhidkova O.B., Druzina A.A., Nazarov A.A., Timofeev S.V., Sivaev I.B., Bregadze V.I.
Журнал: Russian Chemical Bulletin
Том: 72
Номер: 4
Год издания: 2023
Издательство: Springer Nature
Местоположение издательства: Switzerland
Первая страница: 1059
Последняя страница: 1065
DOI: 10.1007/s11172-023-3871-8
Аннотация: Boron-containing conjugates of cholesterol were synthesized by the copper(I)-catalyzed 1,3-dipolar [3+2] cycloaddition reactions of cobalt and iron bis(dicarbollide) azide derivatives with alkynyl cholesterol. The antiproliferative activity (IC50) of the conjugates was evaluated against a series of human cell lines by the MTT assay. All conjugates were shown to be nontoxic (IC50 >200 umol L–1) and to be applicable for the preparation of boron-containing liposomes as potential drugs for boron-neutron capture therapy (BNCT) of cancer.
Добавил в систему: Сиваев Игорь Борисович

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