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Synthesis of tetraalkoxyaryldihydrobenzo[g]indazoles from metabolites of dill and parsley seeds essential oilстатья
- Авторы: Varakutin Alexander E., Shinkarev Ilia Yu, Muravsky Egor A., Nasyrova Darina I., Samigullina Aida I., Semenova Marina N., Semenov Victor V.
- Журнал: Tetrahedron
- Том: 137
- Номер: 8
- Год издания: 2023
- Издательство: Pergamon Press Ltd.
- Местоположение издательства: United Kingdom
- Номер статьи: 133365
- DOI: 10.1016/j.tet.2023.133365
- Аннотация: An efficient method for the conversion of available plant allylpolyalkoxybenzenes into unsubstituted and arylsubstituted polymethoxylated aryldihydrobenzo[g]indazoles, analogues of combretastatin A4, has been developed. The selective demethylation of target compounds resulted in indazoles with different position of OH-group. Their structure was confirmed by X-ray analysis. A sea urchin embryo assay revealed the lack of tubulin-related antimitotic activity of aryldihydrobenzo[g]indazoles with systemic toxicity of a compound featuring OH group and 1-unsubstituted pyrazole ring.
- Добавил в систему: Муравский Егор Александрович