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Development of new approach for the synthesis of 6-perfluoroalkyl substituted allene benzazecines and study of the nature of properties due to the presence of perfluoroalkyl groupsстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 мая 2024 г.
- Авторы: Titov Alexander A., Obydennik Arina Y., Borisova Tatiana N., Sorokina Elena A., Voskressensky Leonid G., Varlamov Alexey V., Thi Tuyet Anh Dang, Le Nhat-Thuy-Giang, Le Tuan Anh
- Журнал: Journal of Fluorine Chemistry
- Том: 267
- Год издания: 2023
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Номер статьи: 110109
- DOI: 10.1016/j.jfluchem.2023.110109
- Аннотация: New approach for the introduction of a perfluoroalkynyl fragment into 1-R2–2-methyl-1,2,3,4-tetrahydroisoquinolines has been developed. Synthesized 1,1-disubstituted isoquinoline compounds under the action of methyl propiolate (24 °C) and acetylacetylene (-17 °C) in trifluoroethanol are converted into 6-perfluoroalkyl substituted allene benzazecines. The synthesized isoquinoline derivatives 2, and benzazecines 3–4 were evaluated against four cancer cell lines. The results revealed that compound 2h (R2 = C6H4-p-OMe; RF = CF(CF3)2) displayed good cytotoxic effects on four tested cell lines with IC50 values ranging from 5 to 50 μM.
- Добавил в систему: Малошицкая Ольга Александровна