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Synthesis and in vitro evaluation of 227Th-bombesin complexesстатья Тезисы
- Авторы: Lunyova K., Klementyeva O., Bruskin A., Lunev A.
- Сборник: Annual Congress of the European Association of Nuclear Medicine October 15-19, 2022 Barcelona, Spain Abstracts
- Том: 49
- Год издания: 2022
- Место издания: Springer Science and Business Media LLC Barcelona, Spain
- Первая страница: 426
- Последняя страница: 427
- Номер статьи: EP-008
- DOI: 10.1007/s00259-022-05924-4
- Аннотация: Target alpha-therapy can deliver high radiationlocalized burden to cancer cells selectively as well as the tumor, while minimizing toxicity to normal cell. Thorium-227 can be used to radionuclide therapy (RNT) it can form highly stable chelator complexes (unlike radium-223). Bombesin (BBN) is a 14-aminoacidpeptide isolated from frog skin. Over-expression of receptors for BBN have been reported to be found on the cell surfaces of several malignant tissues, particularly in the cases of prostate and breast cancer. Up to now, many types of radiolabeled BBN analogues have been designed to target gastrin-releasing peptide receptor expressing tumors.The in vitro studies on mouse melanoma cells B16F10 showed a high level of total accumulation and internalization 227Th-DOTAGABBN compared with 227Th-DOTA-BBN. Based on the results we canconclude that the prospects for further study of 227Th-DOTAGA-BBN complex as a radiopharmaceutical for RNT of malignant tumor.
- Добавил в систему: Клементьева Ольга Евгеньевна