Synthesis of vitamin B12 derivatives with sodium hydroxymethanesulfinateстатья
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Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
Аннотация:The reaction of cyanocobalamin (CNCbl) with sodium hydroxymethanesulfinate (HMS) was studied over a wide range of pH (4–11) under aerobic conditions. CNCbl is destroyed in the presence of HMS in aqueous solution to form uncolored substances. The accumulation of stable yellow corrinoids (SYCs) preceded these changes at pH ≥ 8. The major stable yellow corrinoid is (15R)-Co, Coß — dicyano-13-dehydro-15-hydro-l5-hydroxycob(III)alamin. The yield of this SYC is 25%, and the stability of this compound decreases significantly with increasing concentrations of HMS, pH and temperature.