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Differential expression of microRNAs targeting genes associated with the development of high-grade gliomasстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
- Авторы: Kit Oleg I., Pushkin Anton A., Alliluyev Ilya A., Timoshkina Nataliya N., Gvaldin Dmitry Y., Rostorguev Eduard E., Kuznetsova Nataliya S.
- Журнал: Egyptian Journal of Medical Human Genetics
- Том: 23
- Номер: 1
- Год издания: 2022
- Издательство: Aim Shams University
- Местоположение издательства: Egypt
- Номер статьи: 31
- DOI: 10.1186/s43042-022-00245-5
- Аннотация: Abstract Background: Highly malignant high-grade gliomas are tumors of the central nervous system (CNS). They are solid tumors arising from transformed cells of the brain and/or the spinal cord. In recent years, the expression of genes and regulating miRNAs in glial brain tumors has been actively studied. The present study is devoted to assessing the expression levels of miR-215-5p, miR-22-3p, miR-122-5p, miR-107, miR-324-5p, miR-34a-5p, miR-155. -5p, miR-21-5p, miR-497-5p, miR-330-3p, miR-146a-5p, miR-92a-1-5p, miR-326 and target genes EGFR, SMAD4, SMAD7, SMO, NOTCH1, NOTCH2, HIF1A, EGLIN1/3, KDM1B, KDM1A, MSI1, MSI2, TET1 in high-grade glioma tissues. Results: As a result of the analysis of the levels of relative expression of the studied genes, there are significant changes (p < 0.05) in tumor tissue for genes: EGFR, SMAD4, SMAD7, SMO, HIF1A, EGLN1/3. We obtained data on a significant change (p < 0.05) in the levels of relative expression for microRNA: hsa-miR-215-5p, hsa-miR-22-3p, hsa- miR-122-5p, hsa-miR-107, hsa-miR-324-5p, hsa-miR-155-5p, hsa-miR-21-5p, hsa-miR-330-3p, hsa-miR-326. Data on the association of overall survival in patients with high-grade glioma and the level of relative expression of the EGFR and HIF1A genes were obtained. The obtained data demonstrate the association of overall survival of patients with high- grade glioma and the level of relative expression of EGFR, HIF1A and hsa-miR-22-3p, hsa-miR-107 and hsa-miR-330-3p. Conclusions: The obtained data on the expression of genes and microRNAs expand the understanding of the biol- ogy of the development of high-grade glial tumors. These data demonstrate new potential therapeutic and prognos- tic goals in high-grade gliomas. Keywords: High-grade gliomas, Gene expression, Expression of miRNAs, Prognostic markers, EGFR, HIF1A
- Добавил в систему: Росторгуев Эдуард Евгеньевич