Raft Formation in Biological Membranes:A Molecular Dynamics Simulation Study

Bozdaganyan, M.E.; Shaitan, K.V.

Авторы: Bozdaganyan M.E., Shaitan K.V.
Журнал: Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology
Том: 8
Номер: 4
Год издания: 2014
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 290
Последняя страница: 296
DOI: 10.1134/S1990747814040035
Аннотация: Rafts are nanoscale domains in membranes rich with sphingomyelin and cholesterol. The process of raft formation was studied using molecular dynamics simulation method. The model membranes con tained three types of lipids: cholesterol (CHOL), Derythronpalmitoyl sphingomyelin (SM), and 1palm itoyl2oleoylsnglycero3phosphatidylcholine (POPC). One of the model systems had an SM and CHOLenriched domain. It was shown that in this case raft domain spontaneously became thicker and passed from phase Ld to phase Lo. In another model system—a cubic box with mixed SM, CHOL, and POPC—a raftfree bilayer structure in Lo phase was formed. In the third system that had the same lipids mixed in the bilayer structure, a spontaneous formation of the raft was observed. The raft area was 72 nm2 and the content of CHOL and SM in the raft was 2.4 and 3fold higher respectively than in the nonraft membrane. Keywords: molecular dynamics, raft, cholesterol, sphingomyelin DOI: 10.1134/S1990747814040035 Original Russian Text © M.E. Bozdaganyan, K.V. Shaitan, 2014, published in Biologicheskie Membrany, 2014, Vol. 31, No. 4, pp. 244–251.
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