Antioxidant Action on the Level of Reactive Oxygen Speciesin Normal and Transformed Fibroblastsстатья
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Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.
Аннотация:The level of reactive oxygen species (ROS) in normal (3T3) and transformed (3T3_SV40) murine
fibroblasts treated with antioxidants for 15 min was studied using a carboxy-H2DCFDA fluorescent probe. It was shown that N-acetylcysteine (NAC) decreased the ROS level in both cell types. Antioxidant alpha-lipoic acid (ALA) and its reduced form dihydrolipoic acid (DHLA) caused a prooxidant effect. ALA and DHLA in the concentration range from 0.1–1.25 mM increased the ROS level in a dose-dependent manner in both cell types. The ability of ALA and DHLA to activate hydrogen_peroxide production is discussed.