Influence of Different Methods of Obtaining Solid Dispersions and Crystals of Fenbendazole on Biological Activityстатья
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Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
Аннотация:Fenbendazole (FBZ) is one of the most widely used drugs in veterinary practice. Modification of its physicochemical properties, in particular the solubility parameter, contributes to a change in its biological activity, which is shown in the model of trichinosis in white mice. The paper presents an analysis of methods for obtaining new preparations of fenbendazole: solid dispersions of fenbendazole with polymers, as well as combinations with polymers and succinic acid (SA) and mixed crystals of PBZ with SA; the content of the active substance, stability and effect on biological activity were studied.