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The Rab5 effector FERRY links early endosomes with mRNA localizationстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Schuhmacher Jan S., tom Dieck Susanne, Christoforidis Savvas, Landerer Cedric, Davila Gallesio Jimena, Hersemann Lena, Seifert Sarah, Schäfer Ramona, Giner Angelika, Toth-Petroczy Agnes, Kalaidzidis Yannis, Bohnsack Katherine E., Bohnsack Markus T., Schuman Erin M., Zerial Marino
- Журнал: Molecular Cell
- Том: 83
- Номер: 11
- Год издания: 2023
- Издательство: Cell Press
- Местоположение издательства: United States
- Первая страница: 1839
- Последняя страница: 1855
- DOI: 10.1016/j.molcel.2023.05.012
- Аннотация: Localized translation is vital to polarized cells and requires precise and robust distribution of differentmRNAs and ribosomes across the cell. However, the underlying molecular mechanisms are poorly understood and important players are lacking. Here, we discovered a Rab5 effector, the five-subunit endosomal Rab5 and RNA/ribosome intermediary (FERRY) complex, that recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction. FERRY displays preferential binding to certain groups of transcripts, including mRNAs encoding mitochondrial proteins. Deletion of FERRY subunits reduces the endosomal localization of transcripts in cells and has a significant impact on mRNA levels. Clinical studies show that genetic disruption of FERRY causes severe brain damage. We found that, in neurons, FERRY co-localizes with mRNA on early endosomes, and mRNA loaded FERRY-positive endosomes are in close proximity of mitochondria.FERRY thus transforms endosomes into mRNA carriers and plays a key role in regulating mRNAdistribution and transport.
- Добавил в систему: Калайдзидис Яннис Леонтьевич