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Первый опыт использования индуктора эндогенных интерферонов на этапах лучевой терапии рака орофарингеальной зоныстатья
- Авторы: Франциянц Е.М., Розенко Л.Я., Гусев В.И., Евсегнеева И.В., Беккер Г.П., Гусарева М.А., Зыкова Т.А., Донская А.К., Крохмаль Ю.Н., Кошелева Н.Г., Солнцева А.А.
- Журнал: РМЖ. Медицинское обозрение
- Том: 4
- Номер: 3
- Год издания: 2020
- Издательство: ООО «Медицина-Информ»
- Местоположение издательства: Москва
- Первая страница: 161
- Последняя страница: 168
- DOI: 10.32364/2587-6821-2020-4-3-161-168
- Аннотация: Background: in recent years, human papillomavirus (HPV) becomes increasingly important to the pathogenesis of oropharyngeal cancer. As a result, the prognosis and treatment for this disorder radically changes since the efficacy of selective anti-HPV medications is unknown. Aim: to assess the therapeutic potentiality of Allokin-alpha for the radiotherapy of HPV-positive patients with oropharyngeal cancer. Patients and Methods: 40 patients with oropharyngeal cancer stage III-IV (study group: 19 patients; control group: 21 patients) underwent 3D conformal radiotherapy using 6 MeV linear particle accelerator (standard radiation exposure). In the study group, 1.0 mg of Allokin-alpha was administered subcutaneously every other day including radiation-free days (excepting scheduled treatment breaks). In total, 24.0±2.0 mg of Allokin-alpha were administered for two split-course radiotherapies. Results: after the first course of radiotherapy, pain resolution was reported in 59.7% of study group patients vs. 23.8% of control group patients, the resolution of foreign body sensation in the throat in 36.8% vs. 19%, and the resolution of weakness, sub-febrile temperature, and bad breath in 58.4% vs. 28.6%. The total controlled effect was achieved in 94.7% of study group patients vs. 71.4% of control group patients (р<0.05), i.e., tumor resorption was observed in 68.4% vs. 42.9% and lymph node metastasis regression in 47.3% vs. 9.6% (p<0.05). After the first course of radiotherapy, pellicle epithelitis was less common in the study group compared to the control group (28.5% vs. 5.3%, р<0.05). Conclusion: preliminary clinical data demonstrate the utility of Allokin-alpha administering during the radiotherapy of oropharyngeal cancer. Further studies on the potential radioprotective properties of Allokin-alpha are required to address the possible deintensification of radiation exposure.
- Добавил в систему: Зыкова Татьяна Алексеевна