Synthesis of non-natural L-alanine derivatives using the aza-Cope–Mannich reactionстатья
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Дата последнего поиска статьи во внешних источниках: 19 июня 2014 г.
Аннотация:Non-natural L-alanine derived trans-octahydrocyclohepta[b]pyrroles were synthesized with high enantiomeric purity using the aza-Cope–Mannich reaction. The study showed that the conditions of the aza-Cope–Mannich reaction and metal catalysed cyclization are mild enough to be applied to the synthesis of molecules with stereocenters, which are prone to racemization. We believe that these compounds will be of interest to medicinal chemists.