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EVALUATION OF THE METABOLIC SYNDROME EFFECT ON THE COURSE OF CHRONIC HEART FAILUREстатья
- Авторы: MARGULIS M.E., CHERNIK T.
- Журнал: МОЛОДЕЖНЫЙ НАУЧНЫЙ ВЕСТНИК
- Том: 9
- Номер: S2
- Год издания: 2020
- Первая страница: 371
- Последняя страница: 372
- Аннотация: Metabolic syndrome (MS) - an independent factor in the formation and progression of chronic heart failure (CHF) due to activation of systemic inflammation, lipid profile disorders and myocardial remodeling. The aim of the study - to analyse the effects of MS on the clinical course of CHF. The study included 124 patients with CHF. According to the presence or absence of MS 2 groups were formed: 61 patients with CHF only and 63 patients with CHF and MS. The list of diagnostic studies included: anthropometric measurements, exercise tolerance testing, bioimpedance measurement, echocardiography, assessment of quality of life (QOL), laboratory tests (lipid panel, NT-proBNP, IL-1β, IL-6, TNF-α). The survey of these two groups revealed statistically significant differences between of them. The results of 6 MWT in patients with CHF and MS were lower in compared with patients with CHF only (222 ± 9.8 and 256 ± 9.4 m, respectively (p = 0.0159)); the severity of dyspnea after 6 MWT was higher (4.73 ± 0.12 and 2.84 ± 0.13 points, respectively (p < 0,001)); NT-proBNP was higher: 2077 ± 61.29 pg / ml and 1217 ± 44.25, respectively (p <0.001); mean value of IL-1β was higher (p <0.001), the mean value of IL-6 was higher (p <0.001), the level of TNF-α was higher, respectively (p <0.001), the average value of the total fat mass was 37.67 ± 0.62 and 20.86 ± 0.80%, respectively (p <0.001), the average visceral fat mass was 16.08 ± 0.47 and 9.04 ± 0.39%, respectively (p <0.001), the average body water was 46.22 ± 0.79 and 40.32 ± 0.81%, respectively (p <0.001), LVEDV and LVESV were higher: 5.63 ± 0.09 and 5.25 ± 0.05 cm, respectively (p = 0.0003); 4.11 ± 0.07 and 4.06 ± 0.06 cm, respectively (p = 0.0038); LVEF was lower: 40.03 ± 1.23 and 44.18 ± 0.65%, respectively (p = 0.0038) and QOL was lower as well: 63.17 ± 1.96 and 32.88 ± 1.48 points, respectively (p <0.001). MS causes subclinical inflammation, which is manifested by an increase in inflammatory cytokines, NT-proBNP level, and a decrease in exercise tolerance, which worsens the prognosis
- Добавил в систему: Маргулис Мария Евгеньевна