|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Changes in mononuclear cell subsets in capillary and venous blood of patients with psoriasis depending on the treatmentстатья
Статья опубликована в журнале из списка RSCI Web of Science
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Sennikova S.V., Toptygina A.P.
- Журнал: Российский иммунологический журнал
- Том: 25
- Номер: 4
- Год издания: 2022
- Издательство: ФГБУ "Издательство "Наука"
- Местоположение издательства: Москва
- Первая страница: 521
- Последняя страница: 528
- DOI: 10.46235/1028-7221-1159-cim
- Аннотация: Traditionally, topical glucocorticoids are used to treat psoriasis, but such treatment has a short-term effect and is fraught with various complications with long-term use. A detailed study of the immunopathogenesis of psoriasis has made it possible to use bioengineered drugs that block the main cytokines. It has been shown that IL-36 plays an important regulatory role in the pathogenesis of psoriasis. The aim of the study was to study the effect of therapy of patients with psoriasis with topical glucocorticoid hormone or IL-36 receptor antagonist (RAIL-36) on the clinical course of psoriasis and the subsets of mononuclear cells composition of venous and capillary blood taken near the focus of inflammation. 16 patients with psoriasis (group 1a) received 0.1% mometasone cream for 14 days, 20 patients of group 1b received a gel containing 0.4% recombinant RAIL-36 for 14 days. 20 healthy adults made up the control group. Treatment efficacy was assessed by PASI, DISHS and DLQI indices. 19 lymphocyte subsets and 3 monocyte subsets were assessed by four-color staining of whole capillary and venous blood with erythrocyte lysis using BD Biosciences (USA) technologies and reagents. It was shown that both drugs led to a decrease in the severity of symptoms of the disease at the end of treatment, but 2 weeks after the end of treatment in group 1a, the index levels almost returned to the original level, and in group 1b, the reduced index levels persisted 2 weeks later. Significant deviations (greater in capillary blood) were revealed in the levels of several subsets in patients with psoriasis compared with healthy ones. As a result of treatment, changes in the levels of subsets common for the two groups and characteristic differences for the two treatment options, more pronounced in capillary blood, were revealed. Both preparations used are suitable for the treatment of psoriasis.
- Добавил в систему: Топтыгина Анна Павловна