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Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparationsстатья
- Автор: Kolesnichenko Irina
- Журнал: ACS Omega
- Том: 43
- Номер: 8
- Год издания: 2023
- Первая страница: 40229
- Последняя страница: 40241
- DOI: 10.1021/acsomega.3c03946
- Аннотация: For the eective dosage of newly developedophthalmic drugs, an assessment of the dynamics of theirconcentration in lacrimal fluid over time is required. To express thedetection and identification of drugs, new methods are needed thatmust meet numerous requirements, not the least of which areselectivity, speed, the absence of false-negative results, and costeectiveness. The possibility of identifying anesthetics (sevoflurane)in lacrimal fluid has been studied using a new electrochemical methodof multisensory inversion voltammetry in the electronic tongue andelectronic nose format. The measurements were performed on aplanar electrode, which is a three-electrode structure. The solution ofthe test system consisted of 0.05 M KCl, which contained the metalcations Zn2+, Cd2+, Pb2+, Co2+, and Hg2+ at a concentration of 5 × 10−5 M. It is shown that this method is eective for thedetermination of anesthetics, and the dynamics of changes in their concentration over time are examined. This study aimed toresearch the behavioral pharmacokinetics in the lacrimal fluid of the opioid drug sevoflurane in pediatric ophthalmology usingmultisensory stripping voltammetry in patients during strabismus correction surgery. The dynamics of changes in theirconcentrations over time were examined. After the instillation of the anesthetics in patients, their concentrations in the tear fluidremained unchanged within 10 min. The list of organic substances that can be determined by multisensory stripping voltammetryhas been extended. The class of organic substances determined by the method of multisensory inversion voltammetry has been
- Добавил в систему: Колесниченко Ирина Ивановна