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High-Functioning Adults with Autism Spectrum Disorder differ from neurotypical adults under exploration-exploitation dilemma: MEG studyстатья
Дата последнего поиска статьи во внешних источниках: 19 июня 2024 г.
- Авторы: Pultsina K.I., Tretyakova V.D., Miasnikova A.S., Prokofyev A.O., Kozunova G.L., Rytikova A.М., Stroganova T.A., Chernyshev B.V.
- Журнал: International Journal of Psychophysiology
- Том: 188
- Год издания: 2023
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 103
- DOI: 10.1016/j.ijpsycho.2023.05.265
- Аннотация: Adults with autism spectrum disorder experience difficulties with decisions and learning under uncertainty. Our study aimed to reveal specificities in brain functioning during decision-making and feedback evaluation in high functioning adults with autistic spectrum disorder, compared with neurotypical adults.23 adults with high functional autism and 23 gender- and age-matched neurotypical adults participated in the study. We recorded MEG while participants were performing a two-choice probabilistic gambling task with monetary gains and losses. The high-payoff stimulus was associated with greater probability of wins, while the low-payoff one – with greater probability of losses. We took into analysis only the recording spans during which participants’ behaviour evidenced strong preference for the high-payoff stimulus. Choosing the high-payoff and the low-payoff stimuli was considered as exploitatory and exploratory choices correspondingly. We analysed the power of beta oscillations (16-30 Hz) in two windows: during decision making (-900 – -100 ms before the response) and late feedback processing (500 - 900 ms after feedback). We observed a strong suppression of beta power during decision-making in both groups. Yet, we found a highly significant group✕choice type interaction over parietal areas. In neurotypical participants, beta suppression was significantly deeper for exploratory choices compared with exploitatory ones, while in the autistic group suppression was equally strong for both choice types.During feedback processing, we found a significant effect of group✕feedback✕choice type interaction. In neurotypical adults, there was a significant differential effect in the brain response to feedback sign after exploratory choices, with negative but not positive feedback evoking strong left frontal beta synchronisation. Yet, in autistic adults, no such differential effect was observed, with equally weak beta synchronization to both feedback signs.Our data reveal that neurotypical participants invest more resources and effort during a ‘risky’ decision to explore compared with a ‘safe’ exploitative decision, evidencing that explorative decisions are accompanied by a conflict. Yet autistic persons invest almost equally strong processing and effort into both explorative and exploitative decisions, probably because they fail to set relevant priorities.We assume that late beta synchronisation after negative feedback in explorative choices relates to reactivation of the cortical representation of the utility model related to exploitative decisions. Absence of such beta synchronization may suggest that adults with autistic spectrum disorder do not have a sufficiently strong utility model or fail to prioritize and utilize action outcomes.
- Добавил в систему: Чернышев Борис Владимирович