Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic health

Dinas, P.C.; Nintou, E.; Vliora, M.; Pravednikova, A.E.; Sakellariou, P.; Witkowicz, A.; Kachaev, Z.M.; Kerchev, V.V.; Larina, S.N.; Cotton, J.; Kowalska, A.; Gkiata, P.; Bargiota, A.; Khachatryan, Z.A.; Hovhannisyan, A.A.; Antonosyan, M.A.; Margaryan, S.; Partyka, A.; Bogdanski, P.; Szulinska, M.; Kregielska-Narozna, M.; Czepczyński, R.; Ruchała, M.; Tomkiewicz, A.; Yepiskoposyan, L.; Karabon, L.; Shidlovskii, Y.; Metsios, G.S.; Flouris, A.D.

Авторы: Dinas Petros C., Nintou Eleni, Vliora Maria, Pravednikova Anna E., Sakellariou Paraskevi, Witkowicz Agata, Kachaev Zaur M., Kerchev Victor V., Larina Svetlana N., Cotton James, Kowalska Anna, Gkiata Paraskevi, Bargiota Alexandra, Khachatryan Zaruhi A., Hovhannisyan Anahit A., Antonosyan Mariya A., Margaryan Sona, Partyka Anna, Bogdanski Pawel, Szulinska Monika, Kregielska-Narozna Matylda, Czepczyński Rafał, Ruchała Marek, Tomkiewicz Anna, Yepiskoposyan Levon, Karabon Lidia, Shidlovskii Yulii, Metsios George S., Flouris Andreas D.
Журнал: PLoS ONE
Том: 17
Номер: 4
Год издания: 2022
Издательство: Public Library of Science
Местоположение издательства: United States
Первая страница: e0266386
DOI: 10.1371/journal.pone.0266386
Аннотация: Contribution of UCP1 single nucleotide polymorphisms (SNPs) to susceptibility for cardiometabolic pathologies (CMP) and their involvement in specific risk factors for these conditions varies across populations. We tested whether UCP1 SNPs A-3826G, A-1766G, Ala64Thr and A-112C are associated with common CMP and their risk factors across Armenia, Greece, Poland, Russia and United Kingdom. This case-control study included genotyping of these SNPs, from 2,283 Caucasians. Results were extended via systematic review and meta-analysis. In Armenia, GA genotype and A allele of Ala64Thr displayed ~2-fold higher risk for CMP compared to GG genotype and G allele, respectively (p<0.05). In Greece, A allele of Ala64Thr decreased risk of CMP by 39%. Healthy individuals with A-3826G GG genotype and carriers of mutant allele of A-112C and Ala64Thr had higher body mass index compared to those carrying other alleles. In healthy Polish, higher waist-to-hip ratio (WHR) was observed in heterozygotes A-3826G compared to AA homozygotes. Heterozygosity of A-112C and Ala64Thr SNPs was related to lower WHR in CMP individuals compared to wild type homozygotes (p<0.05). Meta-analysis showed no statistically significant odds-ratios across our SNPs (p>0.05). Concluding, the studied SNPs could be associated with the most common CMP and their risk factors in some populations.
Добавил в систему: Праведникова Анна Эрнестовна

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Prevalence of uncoupling protein one genetic polymorphisms and their relationship with cardiovascular and metabolic healthстатья Исследовательская статья

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