Аннотация:This paper considers last highlights in synchronous and follow-up optical observationsof high energy astrophysical phenomena by MASTER Global Robotic Net.Such extreme Universe sources includes gamma-ray bursts, gravitational waveevents, detected by LIGO/Virgo, fast radio bursts, high energy neutrino sources andothers. Some of the neutrinos detected by ground-based facilities owe their birthsto supermassive black holes - blazars, which are in a special anxious state with highstatistical reliability. We discovered the effect of a rapid decrease in the brightnessof the blazar PKS 0735+17 at the time of the multiple detection of the high-energyneutrino event IceCube-211208A. This decrease in brightness within several hourswas detected with a high confidence (SNR 10) in comparison with a multi-day brighteningstate of the blazar, which was accompanied not only by a maximum increasein the average brightness, but also by an increase in the amplitude of its brightnessfluctuations. Additionally, we analyzed all cases of successful observation of blazarsaround neutrino events and obtained statistically reliable indications of the relationshipbetween neutrino events and optical activity of blazars in the doubled error boxat the 4.2 σ level.