Местоположение издательства:Road Town, United Kingdom
Аннотация:This work is aimed at the preparation of complexes of chitosan and hydrophobically modified (HM) chitosan withan anionic surfactant sodium dodecylbenzene sulfonate (SDBS), and at the study of the virucidal activity of thecomplexes and their components against SARS-CoV-2. It is shown that the introduction of a sufficient amount (4mol%) of hydrophobic n-dodecyl side groups provides the activity of HM chitosan against SARS-CoV-2 atmoderate concentrations, at which unmodified chitosan and chitosan containing a lower amount of hydrophobicgroups do not show any activity. Complexes of HM chitosan with SDBS are prepared, which is proven byfluorescence spectroscopy and isothermal titration calorimetry. It is discovered that HM chitosan /SDBS complex ismore active than the polymer without surfactant, and an increase of the amount of hydrophobic groups enhances theactivity.
