|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ИНХС РАН |
||
Influence of copper nanoparticles on the growth characteristics of tumors in white outbreed ratsстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из перечня ВАКДата последнего поиска статьи во внешних источниках: 24 июля 2024 г.
- Авторы: Kachesova P.S., Goroshinskaya I.A., Zhukova G.V., Shalashnaya E.V., Kaplieva I.A., Borodulin V.B.
- Журнал: Исследования и практика в медицине
- Том: 9
- Номер: 3
- Год издания: 2022
- Первая страница: 67
- Последняя страница: 79
- DOI: 10.17709/2410-1893-2022-9-3-5
- Аннотация: Purpose of the study. To study the effect of copper nanoparticles on the characteristics of the transplanted tumors of rats, aswell as to assess the dependence of the effect on the method of administration of nanoparticles.Materials and methods. In experiments on 163 white outbred male rats, 160–200 g, the size and growth rate of transplantedsarcoma 45 and Pliss' lymphosarcoma were determined in dynamics when a suspension of copper nanoparticles in physiologicalsaline was injected intratumorally or intraperitoneally in a total dose of 10 mg/kg. Nanoparticles had a "core-shell" structurewith variable diameter in the range of 30–75 nm. Contrary to other researches, we started the exposure to metal nanoparticlesonly when the tumors had become visible and had grown up to the sizes at which their spontaneous regression was unlikely.Results. In most animals (up to 89 %), significant antitumor effects of copper nanoparticles were obtained up to complete regressionof tumors with large volumes. The effects of nanodispersed copper differed in tumors with different histological structures andgrowth patterns. Experiments on a transplantable, slowly growing sarcoma 45 showed a decrease in the specific tumor growthrate after a single injection of nanoparticles (1.25 mg/kg), a decrease in tumor size could be observed after 4 injections (a totaldose of 5 mg/kg). In the case of a rapidly growing tumor model (Pliss' lymphosarcoma), a decrease in tumor growth rates causedby copper nanoparticles occurred at later stages of exposure, after the animals received nanoparticles at a total dose of 5–10mg/kg. The efficiency depended on the approach of nanoparticles injection.Conclusion. In case of sarcoma 45, intraperitoneal injection of copper nanoparticles was more effective than intratumoral one,while in rats with Pliss' lymphosarcoma intratumoral injection of the nanoparticles had some advantages. The results indicatethat nanodispersed copper is a promising antitumor factor. The mechanisms of regression of large transplanted tumors underthe influence of copper nanoparticles are discussed.
- Добавил в систему: Качесова Полина Сергеевна