Sulfated polysaccharides accelerate gliadin digestion and reduce its toxicityстатья
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Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
Аннотация:Celiac disease and other types of gluten intolerance signifcantly affect the life quality of patients making themrestrict the diet removing all food produced from wheat, rye, oat, and barley flour, and some other products.These disorders arise from protease resistance of poorly soluble proteins prolamins, contained in gluten.Enhanced proteolytic digestion of gliadins might be considered as a prospective approach for the treatment ofceliac disease and other types of gluten intolerance. Herein, we tested a range of sulfated polymers (kappacarrageenan, dextran sulfate and different polysaccharides from brown seaweeds, and a synthetic polystyrenesulfonate) for the ability to activate gliadin digestion by human digestive proteases, pepsin and trypsin. Sulfatedpolysaccharide from Fucus evanescens enhanced proteolytic digestion of gliadins from wheat flour and reduced itscytotoxicity on intestinal epithelial Caco-2 cell culture. Regarding the non-toxic nature of fucoidans, the resultsprovide a basis for polymer-based drugs or additives for the symptomatic treatment of gluten intolerance.