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Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditionsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 июня 2024 г.
- Авторы: Kalenikova E.I., Gorodetskaya E.A., Povarova O.V., Medvedev O.S.
- Журнал: Life
- Том: 14
- Номер: 1
- Год издания: 2024
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 134
- DOI: 10.3390/life14010134
- Аннотация: Coenzyme CoQ10 (CoQ10) is an endogenous lipid-soluble antioxidant that effectively protects lipids, proteins, and DNA from oxidation due to its ability to undergo redox transitions between oxidized and reduced forms. Various oxidative stress-associated infectious and somatic diseases have been observed to disrupt the balance of CoQ10 concentration in tissues. As a high molecular weight polar lipophilic compound, CoQ10 exhibits very limited oral bioavailability, which restrains its therapeutic potential. Nevertheless, numerous studies have confirmed the clinical efficacy of CoQ10 therapy through oral administration of high doses over extended time periods. Experimental studies have demonstrated that in emergency situations, intravenous administration of both oxidizedand reduced-form CoQ10 leads to a rapid increase in its concentration in organ tissues, offeringprotection for organ tissues in ischemic conditions. This suggests that the cardio- and neuroprotectiveefficacy of intravenously administered CoQ10 forms could present new opportunities in treating acute ischemic conditions. Based on these findings, the review provides reasoning supporting furtherresearch and implementation of CoQ10 dosage forms for intravenous administration in emergency situations into clinical practice.
- Добавил в систему: Каленикова Елена Игоревна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 2024-Kalenikova-Prospects_of_Intravenous_Coenzyme_Q10_Admin… | 674,9 КБ | 25 февраля 2024 [omedvedev] | |
| 2. | life-14-00134-v2.pdf | life-14-00134-v2.pdf | 708,8 КБ | 18 января 2024 [omedvedev] |