An expedient cyclization of polyfunctional (aryl)(pyrimidinyl)(pyranyl)methanes into spiro[furo[3,2-c]pyran-2,5’-pyrimidine] scaffoldстатья
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Дата последнего поиска статьи во внешних источниках: 30 января 2024 г.
Аннотация:Spirocyclization of morpholinium 3-[(aryl)(1,3-dimethyl2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-6-methyl-2-oxo-2H-pyran-4-olate by the action of sodium acetate-Nbromosuccinimide system in ethanol at room temperatureresults in spiro[furo[3,2-c]pyran-2,5′-pyrimidine] derivativesin 92-98% yields, the protocol allowing to avoid columnchromatography purification. This new highly efficient andfacile procedure is a convenient way to substitutedunsymmetrical spiro scaffold containing pyrimidine2,4,6-trione and 2,3-dihydro-4H-furo[3,2-c]pyran-4-onefragments promising for biomedical applications