Forces of interaction of red blood cells and endothelial cells at different concentrations of fibrinogen: Measurements with laser tweezers in vitro

Ermolinskiy, P.B.; Maksimov, M.K.; Muravyov, A.V.; Lugovtsov, A.E.; Scheglovitova, O.N.; Priezzhev, A.V.

Авторы: Ermolinskiy Petr B., Maksimov Matvey K., Muravyov Alexey V., Lugovtsov Andrei E., Scheglovitova Olga N., Priezzhev Alexander V.
Журнал: Clinical Hemorheology and Microcirculation
Год издания: 2023
Издательство: I O S press
Местоположение издательства: Netherlands
Первая страница: 1
Последняя страница: 10
DOI: 10.3233/ch-231941
Аннотация: Blood microrheology depends on the constituents of blood plasma, the interaction between blood cells resulting in red blood cell (RBC) and platelets aggregation, and adhesion of RBC, platelets and leukocytes to vascular endothelium. The main plasma protein molecule -actuator of RBC aggregation is fibrinogen. In this paper the effect of interaction between the endothelium and RBC at different fibrinogen concentrations on the RBC microrheological properties was investigated in vitro. Laser tweezers were used to measure the RBC-endothelium interaction forces. It was shown for the first time that the interaction forces between RBC and endothelium are comparable with the RBC aggregation forces, they increase with fibrinogen concentration and reach the saturation level of about 4 pN at the concentration of 4 mg/ml. These results are important for better understanding the mechanisms of RBC and endothelium interaction and developing the novel therapeutic protocols of the microrheology correction in different pathologies.
Добавил в систему: Максимов Матвей Константинович

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Forces of interaction of red blood cells and endothelial cells at different concentrations of fibrinogen: Measurements with laser tweezers in vitroстатья Исследовательская статья

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