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Synthesis of 5-Halo-2ʹ-Azido Derivatives of Cytidine and N-Hydroxycytidine and Evaluation of Their Antiviral Activity on a Panel of RNA Viruses, Including SARS-CoV-2статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Kamzeeva P.N., Kolpakova E.S., Karpova E.V., Borodulina M.O., Yakovchuk E.V., Alferova V.A., Chistov A.A., Belyaev E.S., Kozlovskaya L.I., Aralov A.V.
- Журнал: Russian Journal of Bioorganic Chemistry
- Том: 49
- Номер: 6
- Год издания: 2023
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 1475
- Последняя страница: 1482
- DOI: 10.1134/s1068162023060262
- Аннотация: Coronavirus disease 2019 (COVID-19) is a new global pandemic with high morbidity and mortality caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). N-Hydroxycytidine derivatives show promise for combating COVID-19 and other viral diseases; in particular, molnupiravir has recently been approved for emergency prophylaxis in the early stages after infection with SARS-CoV-2. In the present work, a scheme for the synthesis of 5-halo-2ʹ-azido-substituted cytidine and N-hydroxycytidine derivatives was proposed. The synthesized compounds were tested against a panel of six RNA viruses, including SARS-CoV-2, enteroviruses, CHIKV, and HIV-1. A number of compounds showed ability to inhibit the reproduction of SARS-CoV-2 and CHIKV viruses in the micromolar range without noticeable cytotoxicity. The structures of the leader compounds can be used as a starting point for further design of antiviral agents.
- Добавил в систему: Беляев Евгений Семенович