Аннотация:The use of linear supercharged unfolded polypeptides (SUPs) and oppositely charged surfactants in aqueoussolution has demonstrated impressive adhesive properties. These substances possess biocompatibility,biodegradability and other necessary properties for practical application as a biomedical glue in woundrepair. The success of these substances, coupled with limited knowledge about such systems, provides hopefor enhancing the performance of the final product. One potential approach involves altering the topologyof the polypeptide chain. In this article, we conduct a comparative analysis to examine the behavior of thering and linear chains of a polypeptide in aqueous solution. This analysis utilizes full-atomic computermodeling to monitor the properties of the chains. We investigate the temperature dependence of the shapeand size of individual polypeptides in the solution, as well as the formation of complexes via mixing thepolypeptide chains with oppositely charged sodium dodecylbenzene sulfonate (SDBS) surfactant moleculesin a stoichiometric ratio. Additionally, we explore the cohesive properties of the resulting complex throughpower experiments involving the extraction of single polypeptide chains out of the SUP–SDBS complexes.