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INFLUENCE OF PLANT ANTITOXICANT ON LIPID METABOLISM IN POISONING WITH NICKEL NITRATE ON THE BACKGROUND OF EXPERIMENTAL ATHEROSCLEROSISстатья
- Авторы: Ibragimova Rashad, Gashimovaa Ulduz, Inozemtsev Anatoliy, Ismayilova Khadidja
- Журнал: Baku State University Journal of Life Sciences & Biology
- Том: 1
- Номер: 1
- Год издания: 2024
- Издательство: Baku State University
- Местоположение издательства: Baku
- Первая страница: 38
- Последняя страница: 42
- Аннотация: The purpose of the research was to study the effect of a complex plant antitoxicant from the flora of Azerbaijan on lipid metabolism and lipid peroxidation in chronic nickel nitrate poisoning against the background of experimental atherosclerosis. The studies were carried out on 55 white non-linear male rats weighing 180-250g. The model of atherosclerosis was created according to I. V. Savitsky et al. (2016) and is based on the polyetiological theory of the development of the disease (the animals received Mercazolil – 25 mg/kg of weight, methylprednisolone - 0.17 mg/kg and 15% aqueous solution of ethanol instead of water against the background of an atherogenic diet for 2 weeks). Exposure with nickel nitrate was carried out through drinking water for 60 days at a dose of 2 mg/kg. Lipid metabolism and free radical oxidation processes were monitored by the level of total cholesterol, high-density lipoproteins, low-density lipoproteins, malondialdehyde and catalase in blood serum. The studies were carried out before and after modeling of atherosclerosis and, respectively, after exposure with nickel nitrate on the background of atherosclerosis after 30 and 60 days. In the experimental group, after exposure against the background of experimental atherosclerosis, the animals received a complex antitoxicant (a mixture of licorice, rose hips, grape seeds, oat and burdock bran in the ratio 3:2:1:1:2 - Eurasian patent 201600043 dated 06/25/2018) for a month, which was added at a dose of 8 mg/kg to the drinking water of the drinkers. The results of the study showed that in experimental atherosclerosis after exposure with nickel nitrate, disturbances in lipid metabolism and lipid peroxidation processes were aggravated, it means that heavy metal intoxication is a factor aggravating atherosclerotic processes. There was a direct proportional relationship between the severities of the degree of disorders with the duration of intoxication with nickel nitrate, with a maximum of disorders on the 60th day after exposure. However, in the experimental group with the use of a complex plant antitoxicant, there was a significant improvement in the state of lipid metabolism and oxidative stress that occurred after chronic intoxication with nickel nitrate. The revealed corrective effect of the plant antitoxicant indicates the detoxification effect of this complex herbal preparation and the possibility of its clinical approbation both for the prevention and treatment of chronic nickel nitrate poisoning in patients, especially in those with existing atherosclerotic vascular lesions.
- Добавил в систему: Иноземцев Анатолий Николаевич