Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effects

Shipelin, V.A.; Skiba, E.A.; Budayeva, V.V.; Shumakova, A.A.; Kolobanov, A.I.; Sokolov, I.E.; Maisaya, K.Z.; Guseva, G.V.; Trusov, N.V.; Masyutin, A.G.; Delegan, Y.A.; Kocharovskaya, Y.N.; Bogun, A.G.; Gmoshinski, I.V.; Khotimchenko, S.A.; Nikityuk, D.B.

Авторы: Shipelin Vladimir A., Skiba Ekaterina A., Budayeva Vera V., Shumakova Antonina A., Kolobanov Alexey I., Sokolov Ilya E., Maisaya Kirill Z., Guseva Galina V., Trusov Nikita V., Masyutin Alexander G., Delegan Yanina A., Kocharovskaya Yulia N., Bogun Alexander G., Gmoshinski Ivan V., Khotimchenko Sergey A., Nikityuk Dmitry B.
Журнал: Nanomaterials
Том: 14
Номер: 9
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 768
Последняя страница: 768
DOI: 10.3390/nano14090768
Аннотация: Bacterial nanocellulose (BNC) is being considered as a potential replacement for microcrystalline cellulose as a food additive and a source of dietary fiber due to its unique properties. However, studies on the risks of consuming BNC in food are limited, and it is not yet approved for use in food in the US, EU, and Russia. Aim: This study aims to perform a toxicological and hygienic assessment of the safety of BNC in a subacute 8-week administration in rats. Methods: BNC was administered to male Wistar rats in doses of 0, 1.0, 10.0, and 100 mg/kg body weight for 8 weeks. Various parameters such as anxiety levels, cognitive function, organ masses, blood serum and liver biochemistry, oxidative stress markers, vitamin levels, antioxidant gene expression, and liver and kidney histology were evaluated. Results: Low and medium doses of BNC increased anxiety levels and liver glutathione, while high doses led to elevated LDL cholesterol, creatinine, and uric acid levels. Liver tissue showed signs of degeneration at high doses. BNC did not significantly affect vitamin levels. Conclusion: The adverse effects of BNC are either not dose-dependent or fall within normal physiological ranges. Any effects on rats are likely due to micronutrient deficiencies or impacts on intestinal microbiota.
Добавил в систему: Масютин Александр Георгиевич

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Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effectsстатья

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